人才队伍

姓名:	孙佳姝	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	sunjs(AT)nanoctr.cn

简历：

孙佳姝，国家纳米科学中心研究员，国家杰出青年科学基金获得者（2020年），国家优秀青年科学基金获得者（2016年）。2006年于北京理工大学获学士学位，2010年于美国范德堡大学获工学博士学位，2011年加入国家纳米科学中心。主要从事分析化学与生物医学检测研究，提出了微流控热泳测量的新理念，实现外周血中细胞外囊泡的高灵敏定量检测，为恶性肿瘤早期精准诊断诊疗开辟了新途径。此外，还（1）开发了微流体无标记分离新方法，提高复杂样本中循环肿瘤靶标的分离分辨率；（2）提出了微流控生物传感新策略，提升目标分子的检测灵敏度；（3）发展了微流控精准合成系统，高效制备功能纳米结构用于肿瘤诊疗等应用。近5年以通讯作者在Nature Biomed. Eng., Nature Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., ACS Nano, Nano Lett.等期刊上发表论文40余篇。研究成果被Nat. Nanotechnol. 和Chem. Rev.进行重点评述。有10余项微流控相关发明专利授权。

课题组主页：http://www.nanoctr.cas.cn/sunjiashu/

研究领域：
	微纳生物传感、微流控分离分析、纳米生物医学检测

社会任职：

获奖及荣誉：

代表论著：

1. Tian, Fei^#; Zhang, Shaohua^#; Liu, Chao*; Han, Ziwei; Liu, Yuan; Deng, Jinqi; Li, Yike; Wu, Xia; Cai, Lili; Qin, Lili; Chen, Qinghua, Yuan, Yang; Liu, Yi; Cong, Yulong; Ding, Baoquan; Jiang, Zefei*; Sun, Jiashu*; Protein analysis of extracellular vesicles to monitor and predict therapeutic response in metastatic breast cancer. Nature Communications 2021, 12, 2536.

2. Li, Yike^#; Deng, Jinqi^#; Han, Ziwei; Liu, Chao; Tian, Fei; Xu, Rui; Han, Da*; Zhang, Shaohua*; Sun, Jiashu*; Molecular Identification of Tumor-Derived Extracellular Vesicles using Thermophoresis-Mediated DNA Computation. Journal of the American Chemical Society 2021, 143, 1290-1295.

3. Deng, Jinqi^#; Tian, Fei^#; Liu, Chao*; Liu, Yuan; Zhao, Shuai; Fu, Ting; Sun, Jiashu*; Tan, Weihong*; Rapid One-Step Detection of Viral Particles Using an Aptamer-Based Thermophoretic Assay. Journal of the American Chemical Society 2021, 143, 7261-7266.

4. Han, Ziwei^#; Wan, Fangning^#; Deng, Jinqi^#; Zhao, Junxiang; Li, Yike; Yang, Yunjie; Jiang, Qiao; Ding, Baoquan; Liu, Chao*; Dai, Bo*; Sun, Jiashu*; Ultrasensitive Detection of mRNA in Extracellular Vesicles Using DNA Tetrahedron-Based Thermophoretic Assay. Nano Today 2021, 38, 101203.

5. Zhao, Junxiang^#; Liu, Chao^#; Li, Yike; Ma, Yao; Deng, Jinqi; Li, Lele; Sun, Jiashu*; Thermophoretic Detection of Exosomal microRNAs by Nanoflares. Journal of the American Chemical Society 2020, 142, 4996-5001.

6. Li, Yike^#; Liu, Chao^#; Bai, Xuan^#; Tian, Fei; Hu, Guoqing; Sun, Jiashu*; Enantiomorphic Microvortex-Enabled Supramolecular Sensing of Racemic Amino Acids by Using Achiral Building Blocks. Angewandte Chemie International Edition 2020, 59, 3486-3490.

7. Liu, Chao^#; Zhao, Junxiang^#; Tian, Fei; Cai, Lili; Zhang, Wei; Feng, Qiang; Chang, Jianqiao; Wan, Fangning; Yang, Yunjie; Dai, Bo; Cong, Yulong; Ding, Baoquan; Sun, Jiashu*; Tan, Weihong; Low-Cost Thermophoretic Profiling of Extracellular-Vesicle Surface Proteins for the Early Detection and Classification of Cancers. Nature Biomedical Engineering 2019, 3, 183-193.

8. Liu, Chao; Zhao, Junxiang; Tian, Fei; Chang, Jianqiao; Zhang, Wei; Sun, Jiashu*; λ-DNA- and Aptamer-Mediated Sorting and Analysis of Extracellular Vesicles. Journal of the American Chemical Society 2019, 141, 3817-3821.

9. Liu, Chao^#; Feng, Qiang^#; Sun, Jiashu*; Lipid Nanovesicles by Microfluidics: Manipulation, Synthesis and Drug Delivery. Advanced Materials 2019, 31, 1804788.

10. Liu, Chao; Zhang, Wei; Li, Yike; Chang, Jianqiao; Tian, Fei; Zhao, Fanghao; Ma, Yao; Sun, Jiashu*; Microfluidic Sonication to Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting. Nano Letters 2019, 19, 7836-7844.

承担科研项目情况：
	作为负责人主持面上项目和青年项目；作为子课题负责人主持国家863计划及中国科学院战略性先导科技专项