人才队伍

姓名:	王磊	性别:	男
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	wanglei(AT)nanoctr.cn

简历：

1998,09-2002,07 东北师范大学化学专业学士

2002,09-2005,07 东北师范大学分析化学专业硕士

2005,09-2008,08 全北国立大学(韩国) 高分子纳米工学科博士

2008,08-2009,08 全北国立大学(韩国) Polymer BIN Fusion Research Center 博士后

2009,12-2012,02 北京科技大学材料科学与工程学院讲师

2012,03-2014,03 国家纳米科学中心纳米生物与安全效应实验室助理研究员

2014,03-2017,03 国家纳米科学中心纳米生物与安全效应实验室副研究员

2017,03-现在 国家纳米科学中心 纳米生物与安全效应实验室 特聘研究员

2017,09-2018,02 加州大学戴维斯分校医学院访问学者

研究领域：

基础：

过程仿生（病/生理条件下微纳结构的组装、转化及其生物学效应）

1. 微纳结构分子构筑基元的开发（组装、靶向多肽筛选；双芘荧光染料开发）

2. 分子间相互作用、组装结构和形貌的调控

3. “在体”纳米结构的表征技术联合

4. 仿生细胞外基质形成过程、凝血过程、人类防御素-6抑菌过程等配受体相互作用诱导自放大组装的研究

5. 仿生自噬、分子伴侣蛋白等动态共组装过程的研究等

应用：

1. 基于细胞外基质仿生的纳米多肽网络抗体用于肿瘤诊疗、眼底病治疗

2. 基于人类防御素-6仿生的纳米多肽网络抗体用于病原体诊疗

3. 基于模拟自噬过程的自毁灭纳米清道夫用于神经退行性疾病的治疗

4. 基于细胞外基质仿生的纳米多肽网络用于组织再生。

5. 纳米抗菌材料用于骨内植物抗感染，结核治疗；导尿管抗感染；抗菌涂料等

6. 眼科纳米材料，用于后发性白内障的防治，青光眼等；手术辅助医疗器械等

7. 液晶材料的开发与制备，主要用于药物释放、生物检测、环境、农业领域等

社会任职：

获奖及荣誉：
	2008 第一届优秀博士毕业论文奖，全北国立大学高分子纳米工学科 2006 显示技术杰出科学贡献-默克奖 IMID, 2006, 韩国大邱 2006 优秀发表奖-韩国画像学会26届会议, 2006, 韩国首尔

代表论著：

　　共发表学术论文70余篇，包括Nature Nanotech., Sci. Adv. Nature Commun., Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., ACS Nano, Nano Lett., Biomaterials, Chin. Chem. Lett., Chin. J. Chem.等。

　　2020

　1. Lu Zhang^#, Di Jing^#, Nian Jiang, Tatu Rojalin, Christopher Michael Baehr, Dalin Zhang, Wenwu Xiao, Yi Wu, Zhaoqing Cong, Jian Jian Li, Yuanpei Li, Lei Wang* and Kit S Lam*, Transformable Peptide Nanoparticles Arrest Her2 Signaling and Cause Cancer Cell Death In Vivo, Nature Nanotech., 2020, 15, 145–153.

　2. Pei-Pei Yang^#, Kuo Zhang^#, Ping-Ping He, Yu Fan, Zi-Ming Chen, Da-Yong Hou, Yuan Li, Yu Yi, Dong-Bing Cheng, Jing-Ping Zhang, Lei Wang,* and Hao Wang*, A Biomimetic Platelet Based on Assembling Peptides Initiates Artificial Coagulation, Accepted, Sci. Adv., 2020, aaz4107.

　3. Yu Fan^#, Xiang-Dan Li^#, Ping-Ping He, Xiao-Xue Hu, Kuo Zhang, Jia-Qi Fan, Pei-Pei Yang, Hao-Yan Zheng, Wen Tian, Zi-Ming Chen, Lei Ji, Hao Wang and Lei Wang*, A Biomimic Peptide Recognizes and Traps Bacteria In Vivo as Human Defensin-6, Accepted, Sci. Adv, 2020, aaz4767.

　4. Jia-Qi Fan, Yu Fan, Zi-Jin Wei, Yi-Jing Li, Xiang-Dan Li,* Lei Wang,* and Hao Wang* Targeting N-Cadherin through Transformable Peptide Nanoparticles to Inhibit the Migration and Adhesion of Cancer Cells, Accepted, Chin. Chem. Lett., 2020, CCLET-D-20-00437.

　5. Zi-Ming Chen, Kuo Zhang, Jia-Qi Fan, Yu Fan, Chao Yang, Wen Tian, Yuan Li, Wen-Liang Li, Jing-Ping Zhang, Hao Wang and Lei Wang,* In Situ Construction of Ligand Nano-Network to Integrin αvβ3 for Angiogenesis Inhibition, Accepted, Chin. Chem. Lett., 2020, CCLET-D-20-00327.

　　2019

　 1. Ping-Ping He, Xiang-Dan Li*, Lei Wang* and Hao Wang*, Bispyrene-Based Self-Assembled Nanomaterials: In Vivo Self-Assembly, Transformation, and Biomedical Effects, Acc. Chem. Res., 2019, 52(2), 367-378.

　 2. Li-Li Li, Zeng-Ying Qiao*, Lei Wang* and Hao Wang,* Programmable Construction of Peptide-Based Materials in Living Subjects: From Modular Design and Morphological Control to Theranostics, Adv. Mater., 2019, 1804971.

　 3. Yang Yang^#, Lei Wang^#, Hongqian Cao, Mingjuan Han, Yue Li, Hao Wang*, Bingbing Sun and Junbai Li*, Photodynamic Therapy with Liposomes Encapsulating Photosensitizers with Aggregation-Induced Emission, Nano Lett., 2019, 19(3), 1821-1826.

　　2018

　 1. Qiang Luo,^# Yao-Xin Lin,^# Pei-Pei Yang,^# Yi Wang, Guo-Bin Qi, Zeng-Ying Qiao, Bing-Nan Li, Kuo Zhang, Jing-Ping Zhang,* Lei Wang* and Hao Wang*, A Self-destructive Nanosweeper that Captures and Clears Amyloid β-Peptides, Nature Commun., 2018, 9, 1802.

　 2. Guo-Bin Qi^#, Yu-Juan Gao^#, Lei Wang* and Hao Wang*, Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy, Adv. Mater., 2018, 30(22), 1703444.

　 3. Pei-Pei Yang, Chao Yang, Kuo Zhang, Lei Wang,* and Hao Wang* KLVFF Peptide Functionalized Nanoparticles Capture Aβ42 by Co-Assembly for Decreasing Cytotoxicity, Chin. Chem. Lett., 2018, 29(12), 1811-1814.

　 4. Zhaozhong Li, Yang Li, Dong Wang, Qing Cui, Zhengqiang Li, Lei Wang* and Huai Yang*, Unique Fluorescence Properties of A Self-Assembling Bis-Pyrene Molecule, Chin. Chem. Lett., 2018, 29(11), 1645-1647.

　 5. Chao-Xi Zhou,^# Litao Li,^# Yi-Guang Ma,^# Bing-Nan Li, Guang Li, Zhihang Zhou, Feng Shi, Jie Weng, Cong Zhang, Fenghua Wang, Xu Cui*, Lei Wang* and Hao Wang*, A Bioactive Implant In Situ and Long-Term Releases Combined Drugs for Treatment of Osteoarticular Tuberculosis, Biomaterials, 2018, 176, 50–59.

　　2017

　 1. Yao-Xin Lin, Xue-Feng Hu, Yang Zhao, Yu-Juan Gao, Chao Yang, Sheng-Lin Qiao, Jiao Yan, Pei-Pei Yang, Qian Zeng, Zeng-Ying Qiao, Li-Li Li, Jiang-Bing Xie, Si-Quan Zhu, Xiao-Chun Wu, Lei Wang* and Hao Wang*, Intraocular Lens with Amorphous Nanostructured Rim for High-Efficient Eye-Disease Treatment, Adv. Mater., 2017, 29(34), 1701617.

　 2. Pei-Pei Yang, Qiang Luo, Guo-Bin Qi, Yu-Juan Gao, Bing-Nan Li, Jing-Ping Zhang, Lei Wang*, and Hao Wang*, Host Materials Transformable in Tumor Microenvironment for Homing Theranostics, Adv. Mater. 2017, 29, 1605869.

　 3. Yao-Xin Lin, Sheng-Lin Qiao, Yi Wang, Ruo-Xin Zhang, Hong-Wei An, Zeng-Ying Qiao, Lei Wang,* and Hao Wang* An In Situ Intracellular Self-Assembly Strategy for Quantitative and Temporal Monitoring Autophagy, ACS Nano, 2017, 11 (2), 1826–1839.

　 4. Xiao-Xue Hu, Guo-Bin Qi, Yu-Juan Gao, Yao-Xin Lin, Chao Yang, Pei-Pei Yang, Hong-Xun Hao*, Lei Wang*,and Hao Wang*, Artificial Extracellular Matrix Based on Transformable Nanomaterials for High-Efficient Inhibition of Tumor Invasion and Metastasis, ACS Nano, 2017, 11 (4), 4086–4096.

　 5. Kuo Zhang, Pei-Pei Yang, Jing-Ping Zhang,* Lei Wang* and Hao Wang*, Recent Advances of Transformable Nanoparticles for Theranostics, Chin. Chem. Lett., 2017, 28(9), 1808-1816.

承担科研项目情况：
	作为负责人主持科技部重点研发计划课题1项作为负责人主持国家自然科学基金面上2项和青年项目1项作为负责人教育部留学回国人员启动基金1项作为负责人主持企业研发项目3项作为研究骨干参与国家自然科学基金委重大项目、科技部国家重大研发计划、北京市科委前沿技术培育项目等