人才队伍

姓    名:
高远
性    别:
职    务:
职    称:
研究员
通讯地址:
北京市海淀区中关村北一条11号
邮政编码:
100190
电子邮件:
gaoy(AT)nanoctr.cn

 简历:
 

  高远,研究员,博士生导师。2005年和2011年分别在南京大学强化部(DII)和布兰戴斯大学取得学士学位和博士学位。2011-2013年在布兰戴斯大学做博士后,导师徐兵教授。2013-2015在美国国立卫生研究院(NIH)和国立标准与技术局(NIST)担任助理研究员。长期从事超分子自组装及生物纳米材料方向的研究。发表论文60余篇,包括Sci. Adv., Nat. Commun., JACS, Adv. Mater., Chem. Soc. Rev.等,引用5300余次。已授权8项中国专利,1项美国专利。获NRC RAP Award,主持中科院“率先行动”百人计划(择优支持),国家重点研发计划课题,基金委面上、优秀青年基金等项目。

 

  课题组网页http://www.nanoctr.cas.cn/yuangao/

 


 研究领域:
 

  活体内超分子组装方法学

  超分子组装体的动态变构

  药物递送与生物正交前药

  动态光散射小角中子散射


 社会任职:
 

 获奖及荣誉:
   

 代表论著:
 

1. Gao, Y.; Kuang, Y.; Guo,  Z.-F.; Guo, Z. H.; Krauss, I. J.; Xu, B.* “Enzyme-Instructed Molecular Self-assembly Confers Nanofibers and A Supramolecular Hydrogel of Taxol Derivative” J. Am. Chem. Soc.2009131, 13576-13577.

2. Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B.* “Imaging enzyme-triggered self-assembly of small molecules inside live cells” Nat. Commun., 2012, 3, 1033.

3. Huang, P.*, Gao, Y.*, Lin, J., Hu, H., Liao, H., Yan, X., Tang, Y., Jin, A., Song, J., Niu, G., Zhang, G., Horkay, F., Chen, X.* “Tumor-Specific Formation of Enzyme-Instructed Supramolecular Self-Assemblies as Cancer Theranostics” ACS Nano20159, 9517–9527.

4. Yao, Q., Lin, F., Fan, X., Wang, Y., Liu, Y., Liu, Z., Jiang, X., Chen, P.*, Gao, Y.* “Synergistic Enzymatic and Bioorthogonal Reactions for Selective Prodrug Activation in Living Systems” Nat. Commun., 2018, 9, 5032.

5. Yao, Q., Huang, Z., Liu, D., Chen, J., Gao, Y.* “Enzyme-Instructed Supramolecular Self-Assembly with Anticancer Activity” Adv. Mater., 2019, 31, 1804814.

6. Yao, Q.#, Wang, C.#, Fu, M., Dai, L.*, Li, J.*, Gao, Y.* “Dynamic Detection of Active Enzyme Instructed Supramolecular Assemblies In Situ via Super-Resolution Microscopy” ACS Nano, 2020, 14, 4882-4889.

7. Huang, Z.#, Liu, Y.#, Wang, L., Ali, A., Yao, Q., Jiang, X.*, Gao, Y.* “Supramolecular Assemblies mimicking Neutrophil Extracellular Traps for MRSE Infection Control” Biomaterials, 2020, 253, 120124.

8. Yao, Q., Gao, S., Wu, C., Lin, T.*, Gao, Y.* “Enzymatic non-covalent synthesis of supramolecular assemblies as a general platform for bioorthogonal prodrugs activation to combat drug resistance” Biomaterials, 2021, 277, 121119.

9. Tian, F.#, Yang, M.#, Yao, Q., Song, J., He, J., Shi, X.*, Gao, Y.* “Kinetic Selectivity Dictates the Construction of Cancer Cell-Targeting Enzyme Instructed Supramolecular Assemblies” Nano Today, 2022, 47, 101658.

10. Chen, J.#, Zhang, P.#, Zhao, Y., Zhao, J., Wu, X., Zhang, R., Cha, R., Yao, Q., Gao, Y.* “Nitroreductase-Instructed Supramolecular Assemblies for Microbiome Regulation to Enhance Colorectal Cancer Treatments” Sci. Adv. 2022, 8, eadd2789.


 承担科研项目情况: