人才队伍

姓    名:
王海
性    别:
职    务:
职    称:
研究员
通讯地址:
北京市海淀区中关村北一条11号
邮政编码:
100190
电子邮件:
wanghai@nanoctr.cn

 简历:
 

王海,国家纳米科学中心研究员,博士生导师。2013年在国家纳米科学中心获得博士学位。2014-2016年在The Ohio State University从事博士后研究,2017年晋升为研究科学家。2018年加入University of Maryland任职Assistant Research Professor20193月加入国家纳米科学中心。近年来,在Nature nanotechnologyNature communications, Advanced materials, ACS nano, ACS central science 以及 Advanced functional materials 等杂志发表40余篇论文。

目前主要研究方向:1. 基于微流体的功能性细胞/组织包埋组装技术用于单细胞分析、疾病治疗和组织修复;2. 微纳载药体系的高级组装以及与细胞、组织之间的相互作用 ;3. 多尺度生物材料调控干细胞用于类器官的构建


 研究领域:
 

微纳生物材料的医学应用


 社会任职:
 

 获奖及荣誉:
 

 代表论著:
 

1. Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W. Conroy, Jianhua Yu, Christopher P. Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li, Xiaoming He. Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance. Nature Communications. 2018, 9, 562. (Highly cited paper)

2. Hai Wang, Pranay Agarwal, Shuting Zhao, Jianhua Yu, Xiongbin Lu, Xiaoming He. A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of therasnostic agents. Nature Communications. 2016, 6, 10081

3. Hai Wang, Pranay Agarwal, Shuting Zhao, Jianhua Yu, Xiongbin Lu, Xiaoming He. A Near-Infrared Laser-Activated “Nanobomb” for Breaking  the Barriers to MicroRNA Delivery. Advanced Materials. 2016, 28, 347-355He, X. Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform. Biomaterials 2018; 180: 265-278

4. Hai Wang, Yan Wu, Ruifang Zhao, and Guangjun Nie. Engineering the Assemblies of Biomaterial Nanocarriers for Delivery of Multiple Theranostic Agents with Enhanced Antitumor Efficacy. Advanced Materials. 2013, 251616-22

5. Hai Wang, Pranay Agarwal, Yichao Xiao, Hao Peng, Shuting Zhao, Xuanyou Liu, Shenghua Zhou, Jianrong Li, Zhenguo Liu, Xiaoming He. A Nano-In-Micro System for Enhanced Stem Cell Therapy of Ischemic Diseases. ACS Central Science. 2017, 3 875-885

6. Wei Rao#, Hai Wang#, Jianfeng Han, Shuting Zhao, Jenna Dumbleton, Pranay Agarwal, Wujie Zhang, Gang Zhao, Jianhua Yu, Debra L Zynger, Xiongbin Lu, Xiaoming He*. Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-Like Cells. ACS Nano. 2015, 9:5725-40.

7. Pranay Agarwal#, Hai Wang#, Mingrui Sun, Jiangsheng Xu, Shuting Zhao, Zhenguo Liu, Keith J Gooch, Yi Zhao, Xiongbin Lu, Xiaoming He*. Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery. ACS Nano. 2017, 11, 6691-6702

8. Hai Wang, Pranay Agarwal, Gang Zhao, Guang Ji, Christopher M. Jewell, John P. Fisher, Xiongbin Lu, Xiaoming He*. Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial. ACS Central Science. 2018, 4, 567-581.

9. Feng Li#, Xiao Zhao#, Hai Wang#, Ruifang Zhao, Tianjiao Ji, He Ren, Gregory J Anderson, Guangjun Nie, Jihui Hao*. Multiple Layer-by-Layer Lipid-Polymer Hybrid Nanoparticles for Improved FOLFIRINOX Chemotherapy in Pancreatic Tumor Models. Advanced Functional Materials. 2015, 25, 788-798.

10. Hai Wang, Pranay Agarwal, Shuting Zhao, Jianhua Yu, Xiongbin Lu, and Xiaoming He*. Combined Cancer Therapy with Hyaluronan-Decorated Fullerene-Silica Multifunctional Nanoparticles to Target Cancer Stem-Like Cells. Biomaterials. 2016, 62-73.

11. Hai Wang, Ying Zhao,Yan Wu, Yu-lin Hu, Kaihui Nan, Guangjun Nie, Hao Chen. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials. 2011, 32:8281-90. (Highly cited paper)

12. Hai Wang, Pranay Agarwal, Shuting Zhao, Ronald X Xu, Jianhua Yu, Xiongbin Lu, Xiaoming He. Hyaluronic acid-decorated dual responsive nanoparticles of Pluronic F127, PLGA, and chitosan for targeted co-delivery of doxorubicin and irinotecan to eliminate cancer stem-like cells. Biomaterials. 2015, 72:74-89.

13. Wang, H., Agarwal, P., Liang, Y., Xu, J., Zhao, G.,Tkaczuk, K.H.R., Lu, X.,

14. Xu, J., Liu, Y., Li, Y., Wang, H., Stewart, S., Van der Jeught, K., Agarwal, P., Zhang, Y., Liu, S., Zhao, G., Wan, J., Lu, X., He, X. Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer. Nature Nanotechnology 2019.


 承担科研项目情况: