人才队伍

姓名:	赵潇	性别:	男
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	zhaox@nanoctr.cn

简历：

　　赵潇，国家纳米科学中心研究员。2010-2016年就读于天津医科大学，获得肿瘤学硕士和博士学位。2016-2019年在国家纳米科学中心从事博士后研究工作。2019年10月起在国家纳米科学中心工作，担任研究员和课题组长。研究工作主要聚焦于以合成生物学为基础的生物源性纳米载体的开发与应用，以细菌来源的外膜囊泡为核心，构建了“即插即用”型个体化肿瘤疫苗，对其进行了功能强化、剂型优化等方面的改造并取得了系列性研究成果。已在国际学术期刊上发表SCI论文51篇，其中通讯/第一作者论文25篇，包括1篇Nature Biomedical Engineering、1篇Nature Protocols、1篇Nature Communications、2篇Advanced Materials、4篇ACS Nano、1篇Fundamental Research、1篇Cancer Research。申请发明专利7项（授权4项）。主持国家及省部级项目9项，包括国家重点专项子课题、国自然面上项目、中科院先导C项目骨干等，入选北京市科技新星计划、中科院创新领域青年团队、首届博士后创新人才计划等。

研究领域：
	1、生物源性纳米颗粒的改造和应用 2、纳米人工杂合生物系统的构建和肿瘤免疫诊疗应用 3、纳米尺度下的蛋白质精准组装及其空间生物效应

社会任职：

获奖及荣誉：

代表论著：

1. Yale Yue^#, Jiaqi Xu^#, Yao Li^#, Keman Cheng, Qingqing Feng, Xiaotu Ma, Nana Ma, Tianjiao Zhang, Xinwei Wang, Xiao Zhao^*, Guangjun Nie^*, Controlled production of bacterial outer membrane vesicles in intestine by orally administered bacteria as an effective tumor vaccine, Nature Biomedical Engineering, accepted

2. Xiao Zhao^#, Ruifang Zhao^#, Guangjun Nie^*, Nanocarriers based on bacterial membrane vesicles for cancer vaccine delivery, Nature Protocols, accepted

3. Jie Liang, Keman Cheng, Yao Li, Jiaqi Xu, Yiwei Chen, Nana Ma, Qingqing Feng, Fei Zhu, Xiaotu Ma, Tianjiao Zhang, Yale Yue, Guangna Liu, Xinjing Guo, Zhiqiang Chen, Xinwei Wang, Ruifang Zhao, Ying Zhao, Jian Shi, Xiao Zhao^*, Guangjun Nie^*, Personalized cancer vaccines from bacteria-derived outer membrane vesicles with antibody-mediated persistent uptake by dendritic cells, Fundamental Research, accepted

4. Yao Li^#, Kaiyue Zhang^#, Yao Wu^#, Yale Yue, Keman Cheng, Qingqing Feng, Xiaotu Ma, Jie Liang, Nana Ma, Guangna Liu, Guangjun Nie, Lei Ren^*, Xiao Zhao^*, Antigen capture and immune modulation by bacterial outer membrane vesicles as in situ vaccine for cancer immunotherapy post-photothermal therapy, Small, accepted

5. Yale Yue, Fenfen Li, Yao Li, Yazhou Wang, Xinjing Guo, Zhaoxia Cheng, Nan Li, Xiaotu Ma, Guangjun Nie^*, Xiao Zhao^*, Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy, ACS Nano 2021, 15(9): 15166-15179

6. Keman Cheng^#, Ruifang Zhao^#, Yao Li, Yingqiu Qi, Yazhou Wang, Yinlong Zhang, Hao Qin, Yuting Qin, Long Chen, Chen Li, Jie Liang, Yujing Li, Jiaqi Xu, Gregory J. Anderson, Jian Shi, Lei Ren, Xiao Zhao^*, Guangjun Nie^*, Bioengineered bacteria-derived outer membrane vesicles as a versatile antigen display platform for tumor vaccination via Plug-and-Display technology, Nature Communications 2021, 12(1): 2041

7. Guangna Liu, Motao Zhu, Xiao Zhao^*, Guangjun Nie*, Nanotechnology-empowered vaccine delivery for enhancing CD8 + T cells-mediated cellular immunity, Advanced Drug Delivery Reviews 2021, 176: 113889

8. Jie Liang, Xiao Zhao^*, Nanomaterial-based Delivery Vehicles for Therapeutic Cancer Vaccine Development, Cancer Biology & Medicine 2021, 18(2): 352

9. Yao Li^#, Ruifang Zhao^#, Keman Cheng, Kaiyue Zhang, Yazhou Wang, Yinlong Zhang, Yujing Li, Guangna Liu, Junchao Xu, Jiaqi Xu, Gregory J. Anderson, Jian Shi, Lei Ren, Xiao Zhao^*, Guangjun Nie^*, Bacterial Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition, ACS Nano 2020, 14: 16698

10. Yao Li^#, Xiao Zhao^#, Xiaoli Liu^#, Keman Cheng, Xuexiang Han, Yinlong Zhang, Huan Min, Guangna Liu, Junchao Xu, Jian Shi, Hao Qin, Haiming Fan^*, Lei Ren^*, Guangjun Nie^*, A Bioinspired Nanoprobe with Multilevel Responsive T1 -Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases, Advanced Materials 2020, 32: e1906799

承担科研项目情况：