人才队伍

姓名:	李素萍	性别:	女
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	lisuping@nanoctr.cn

简历：

李素萍，研究员，博士生导师。2011年毕业于北京航空航天大学获工学博士，2015-2017年先后于美国约翰霍普金斯大学医学院和麻省理工学院（MIT）访学合作。研究成果以第一或通讯作者发表在Nature Biotechnology, Nature Biomedical Engineering, Nano letters, Nature Communications等期刊；实现专利转化3项。成果入选2018年中国科学十大进展，入选美国The Scientist 2018“Top Technical Advances”，入选“十三五”科技创新成果展；荣获北京市自然科学奖一等奖（第二完成人），中国药学会科学技术二等奖（第四完成人）。入选万人计划“青年拔尖”、北京市杰青人才计划支持等。

研究领域：
	1）智能纳米药物靶向调控肿瘤血管微环境； 2）靶向干预肿瘤相关血小板功能，抑制肿瘤转移； 3）靶向溶栓、抗栓的新型药物研发。

社会任职：

获奖及荣誉：

代表论著：

1. Suping Li#, Yinlong Zhang#, Jing Wang, Ying Zhao, Tianjiao Ji, Xiao Zhao, Yanping Ding, Xiaozheng Zhao, Ruifang Zhao, Feng Li, Xiao Yang, Shaoli Liu, Zhaofei Liu, Jianhao Lai, Andrew K. Whittaker, Gregory J. Anderson, Jingyan Wei and Guangjun Nie*. Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. Nature Biomedical Engineering, 2017, 1(8): 667-679. (Highlighted by Nat Biomed Eng)

2. Suping Li#; Qiao Jiang#; Shaoli Liu#; Yinlong Zhang#; Yanhua Tian; Chen Song; Jing Wang; Yiguo Zou; Gregory J Anderson; Jing-Yan Han; Yung Chang; Yan Liu; Chen Zhang; Liang Chen; Guangbiao Zhou; Guangjun Nie*; Hao Yan*; Baoquan Ding*; Yuliang Zhao*. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nature Biotechnology, 2018, 36: 258-264. (Highlighted by Nat Biotechnol, Nat Biomed Eng, Nat Rev Cancer, Sci Transl Med, Trends Mol Med, Sci China Chem)

3. Shaoli Liu, Yinlong Zhang, Xiao Zhao, Jing Wang, Chunzhi Di, Ying Zhao, Tianjiao Ji, Keman Cheng, Yongwei Wang, Long Chen, Yingqiu Qi, Suping Li*, Guangjun Nie*. Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability. Nano Letters, 2019, 19(7): 4721-4730.

4. Zifu Li, Chunzhi Di, Suping Li*, Xiangliang Yang* and Guangjun Nie*. Smart Nanotherapeutics Targeting of Tumor Vasculature. Accounts of Chemical Research, 2019, 52, 9, 2703-2712.

5. Suping Li#, Qiao Jiang#, Baoquan Ding*, Guangjun Nie*. Anticancer Activities of Tumor-killing Nanorobots. Trends in Biotechnology, 2019, 6(37): 573-577.

6. Junchao Xu, Yinlong Zhang,* Jiaqi Xu, Guangna Liu, Chunzhi Di, Xiao Zhao, Xiang Li,Yao Li, Ningbo Pang, Chengzhi Yang, Yanyi Li, Bozhao Li, Zefang Lu, Meifang Wang, Kesheng Dai, Rong Yan, Suping Li* and Guangjun Nie*. Engineered Nanoplatelets for Targeted Delivery of Plasminogen Activators to Reverse Thrombus in Multiple Mouse Thrombosis Models. Advanced Materials, 2019, 32(4): e1905145

7. Xin Zeng#, Jie Sun#, Suping Li#, Jiyun Shi, Han Gao, Wei Sun Leong, Yiqi Wu, Minghui Li, Chengxin Liu, Ping Li, Jing Kong, Yi-Zhou Wu, Guangjun Nie*, Yuming Fu* and Gen Zhang*. Blood-triggered generation of Pt nanoparticle functions as an anti-cancer agent. Nature Communications, 2020, 11(1): 567.

8. Suping Li#, Yinlong Zhang#, Shih-Hsin Ho, Bozhao Li, Meifang Wang, Xiongwei Deng, Na Yang, Guangna Liu, Zefang Lu, Junchao Xu, Quanwei Shi, Jing-Yan Han, Lirong Zhang, Yan Wu*, Yuliang Zhao*, Guangjun Nie*. Combining tumour-infarction therapy and chemotherapy via the co-delivery of doxorubicin and thrombin encapsulated in tumour-targeted nanoparticles. Nature Biomedical Engineering, 2020, 4,732–742

9. Bozhao Li, Tianjiao Chu, Jingyan Wei*, Yinlong Zhang, Feilong Qi, Zefang Lu, Chao Gao, Tianjiao Zhang, Ershuai Jiang, Junchao Xu, Jiaqi Xu, Suping Li*, Guangjun Nie*. Platelet membrane-coated nanoparticles enable vascular disrupting agent combining anti-angiogenic drug for improved tumor vessel impairment. Nano letters. 2021, 24;21(6):2588-2595.

承担科研项目情况：