人才队伍

姓    名:
季天骄
性    别:
职    务:
职    称:
研究员
通讯地址:
北京市海淀区中关村北一条11号
邮政编码:
100190
电子邮件:
jitj@nanoctr.cn

 简历:
   

季天骄,国家纳米科学中心研究员,博士生导师。2011年于武汉大学化学基地班专业获学士学位;2016年于国家纳米科学中心获博士学位,并获2017年度中科院百篇优秀博士论文”奖项,导师为聂广军、赵颖研究员。2016-2020年在哈佛医学院(HMS)波士顿儿童医院及麻省理工学院(MIT)进行博士后研究,合作导师为Daniel S. Kohane教授和Robert Langer教授。20209月加入国家纳米科学中心。近年来,在Adv Mater, Nat Commun, Angew Chem Int Ed, Nano Today, Nano Lett, ACS Nano, Small, J Control Release, Adv Funct Mater, Biomaterials, ACS Appl Mater Interfaces等国际重要学术期刊上发表SCI论文近50篇;申请美国发明专利2项,中国发明专利12, 已授权8项。主要从事利用智能纳米药物,针对肿瘤、神经性疼痛等疾病进行诊断和治疗的研究。


 研究领域:
   

微米、纳米药物递送体系在重大疾病治疗中的应用


 社会任职:
 

 获奖及荣誉:
   

2019波士顿儿童医院The Anesthesia Research Distinguished Trailblazer Award

2017年度中国科学院百篇优秀博士学位论文


 代表论著:
   

1. Z. Lian, T. Ji*. Functional Peptide-Based Drug Delivery Systems. J. Mater. Chem. B 2020, 8, 6517-6529. (“Emerging Investigators 2020” invited).

2. T. Ji, J. Lang, B. Ning, F. Qi, H. Wang, Y. Zhang, R. Zhao, X. Yang, L. Zhang, W. Li, X. Shi, Z. Qin, Y. Zhao, G. Nie. Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes. Adv. Mater. 2019, 31, 1804395.

3. T. Ji, D. S. Kohane*. Nanoscale systems for local drug delivery. Nano Today 2019, 28, 10765.

4. J. Lang, X. Zhao, Y. Qi, Y. Zhang, X. Han, Y. Ding, J. Guan, T. Ji*, Y. Zhao*, G. Nie*. Reshaping Prostate Tumor Microenvironment to Suppress Metastasis via Cancer-Associated Fibroblast Inactivation with Peptide-Assembly-Based Nanosystem. ACS Nano 2019, 13, 12357-12371. 

5. C. Weldon, T. Ji (co-first author), M. T. Nguyen (co-first author), A. Rwei, W. Wang, Y. Hao, C. Zhao, M. Mehta, B. Y. Wang, J. Tsui, R. P. Marini, D. S. Kohane*. Nanoscale Bupivacaine Formulations to Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano 2019, 13, 18-25.

6. T. Ji, J. Lang, J. Wang, R. Cai, Y. Zhang, F. Qi, L. Zhang, X. Zhao, W. Wu, J. Hao, Z. Qin, Y. Zhao, G. Nie*. Designing Liposomes to Suppress Extracellular Matrix Expression to Enhance Drug Penetration and Pancreatic Tumor Therapy. ACS Nano 2017, 11, 8668-8678.

7. T. Ji, Y. Zhao, Y. Ding, J. Wang, R. Zhao, J. Lang, H. Qin, X. Liu, J. Shi, N. Tao, Z. Qin, G. Nie, YL. Zhao*. Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-associated Fibroblasts Activation. Angew. Chem. Int. Ed. 2016, 55, 1050-1055.

8. T. Ji, Y. Ding, Y. Zhao, J. Wang, H. Qin, X. Liu, G. Nie*, et al. Peptide Assemblies Integration of Fibroblast Targeting and Cell Penetration Features for Enhanced Antitumor Drugs Delivery. Adv. Mater. 2015, 27, 1865-1873.

9. T. Ji, Y. Zhao, Y. Ding, G. Nie*, Using Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications. Adv. Mater. 2013, 25, 3508-3525.

10. T. Ji, Y. Zhao, J. Wang, X. Zheng, Y. Tian, G. Nie*, et al. Tumor Fibroblast Specific Activation of Hybrid Ferritin Nanocage-based Optical Probe for Tumor Microenvironment Imaging. Small 2013, 9, 2427-2431.

11. W. Zhang, T. Ji, Y. Li, Y. Zheng, M. Mehta, C. Zhao, A. Liu, D.S. Kohane*.  Light-triggered release of conventional localanesthetics from a macromolecular prodrugfor on-demand local anesthesia. Nat. Commun. 2020, doi.org/10.1038/s41467-020-16177-w.


 承担科研项目情况: