人才队伍

姓名:	林耀新	性别:	男
职务:	无	职称:	研究员
通讯地址:	北京市海淀区中关村北一条11号
邮政编码:	100190	电子邮件:	linyx@nanoctr.cn

简历：

林耀新，现任国家纳米科学中心研究员，博士生导师。2017年在中国科学院大学，国家纳米科学中心获得博士学位，主要从事“活体自组装”纳米探针和基于细胞自噬调控的智能纳米药物设计、构建及应用研究。之后在哈佛医学院、布列根妇女医院作为博士后从事mRNA疫苗/药物研究。目前，已在Sci Transl Med, Nat Commun, Adv Mater, Nano Lett, ACS Nano, Small, Biomaterials等国际重要学术期刊上发表SCI论文30余篇，引用超过8500余次。

课题组主要结合材料学、免疫学、药学、化学、生物材料以及纳米技术等手段，设计及构筑智能核酸纳米药物，研究纳米材料的生物效应，发展新型抗病毒和肿瘤免疫治疗纳米技术。

研究领域：
	1、mRNA疫苗载体材料设计和纳米制剂筛选、优化； 2、肿瘤微环境响应智能纳米药物与肿瘤免疫调控治疗； 3、发展基于细胞自噬调控的智能纳米药物或诊疗策略。

社会任职：

获奖及荣誉：

代表论著：

1. Lin, Y.-X.^#; Wang Y.^#; Ding, J.; Jiang, A.; Wang, J.; Yu, M.; Blake, S.; Bieberich, C.; Farokhzad, O.; Mei, L; Wang, H.; Shi, J. Tumor Suppressor Reactivation by mRNA Nanoparticles Induces Anti-Tumor Immunity and Improves Immune Checkpoint Blockade Therapy. Sci. Transl. Med. (2021，13，eaba97).

2. Lin, Y.-X.^#; Wang Y.^#; An, H.-W.; Wang, L.; Shi, J.; Mei, L. and Wang, H. Peptide-based Autophagic Gene and Cisplatin Co-delivery Systems Enable Improve Chemotherapy Resistance. Nano Lett. 2019, 19, 2968-2978.

3. Wang Y.^#; Lin, Y.-X.^#; Wang, J.; Qiao, S.; Liu, Y.; Dong, W.; Wang, J.; An, H.; Yang, C.; Mamti, M.; Wang, L.; Hang, B.; and Wang, H. In Situ Manipulation of Dendritic Cells by an Autophagy-Regulative Nanoactivator Enables Effective Cancer Immunotherapy. ACS Nano 2019, 137, 7568-7577.

4. Luo, Q.^#; Lin, Y.-X.^#; Yang, P.-P.^#; Wang, Y.; Qi, G.; Qiao, Z.-Y.; Li, B.; Zhang, K.; Zhang, J.; Wang, L.; Wang, H. A Self-destructive Nanosweeper that Captures and Clears Amyloid β-peptides. Nat. Commun. 2018, 9, 1802.

5. Lin, Y.-X.^#; Hu, X.-F.^#; Zhao, Y.^#; Gao, Y.-J.; Yang, C.; Qiao, S.-L.; Wang, Y.; Yang, P.-P.; Li, L.-L.; Xie, J.-B.; Zhu, S.-Q.; Wu, X.C.; Wang L. and Wang H. Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment. Adv. Mater. 2017, 29, 1701617.

6. Lin, Y.-X.; Qiao, S.-L.; Wang, Y.; Zhang, R.-X.; An, H.-W.; Ma, Y.; Rajapaksha, R. P. Y. J.; Qiao, Z.-Y.; Wang, L.; Wang, H. An in situ Intracellular Self-Assembly Strategy for Quantitatively and Temporally Monitoring Autophagy. ACS Nano 2017, 11, 1826-1839.

7. Qiao, Z.-Y.^#; Lin, Y.-X.^#; Lai, W.-J.; Hou, C.-Y.; Wang, Y.; Qiao, S.-L.; Zhang, D.; Fang, Q.-J.; Wang, H. A General Strategy for Facile Synthesis and in situ Screening of Self-Assembled Polymer-Peptide Nanomaterials. Adv. Mater. 2016, 28, 1859-1867.

8. Wang, Y.^#; Lin, Y.-X.^#; Qiao, Z.-Y.; An, H.-W.; Qiao, S.-L.; Wang, L.; Rajapaksha, R. P. Y. J.; Wang, H. Self-Assembled Autophagy-Inducing Polymeric Nanoparticles for Breast Cancer Interference in-vivo. Adv. Mater. 2015, 27, 2627-2634.

9. Lin, Y.-X.; Wang Y.; Qiao, S.-L.; An, H.-W.; Wang, L. and Wang, H. “ In vivo self-assembled” nanoprobes for optimizing autophagy-mediated chemotherapy. Biomaterials 2017, 141, 199-209.

10. Lin, Y.-X.; Wang, Y; and Wang H. Recent Advances in Nanotechnology for Autophagy Detection. Small 2017, 13, 1700996.

11. Lin, Y.-X.; Wang, Y.; Qiao, S.-L.; An, H.-W.; Zhang, R.-X.; Qiao, Z.-Y.; Rajapaksha, R. P. Y. J.; Wang, L.; Wang, H. pH-Sensitive Polymeric Nanoparticles Modulate Autophagic Effect via Lysosome Impairment. Small 2016, 12, 2921-2931.

12. Lin, Y.-X.^#; Wang, Y.^#; Blake, S.; Yu, M.; Mei, L.; Wang, H.; Shi, J. RNA Nanotechnology-Mediated Cancer Immunotherapy. Theranostics 2020, 10 (1), 281.

13. Lin, Y.-X.; Gao, Y.-J.; Wang, Y.; Qiao, Z.-Y.; Fan, G.; Qiao, S.-L.; Zhang, R.-X.; Wang, L.; Wang, H. pH-Sensitive Polymeric Nanoparticles with Gold(I) Compound Payloads Synergistically Induce Cancer Cell Death through Modulation of Autophagy. Mol. Pharmaceutics 2015, 12, 2869-2878.

14. Qiao Z.-Y.^#; Lai W.-J.^#; Lin Y.-X.^#; Li D.; Nan X.; Wang Y.; Wang H.; and Fang Q. Polymer-KLAK Peptide Conjugates Induce Cancer Cell Death through Synergistic Effects of Mitochondria Damage and Autophagy Blockage. Bioconjugate Chem. 2017, 28, 1709–1721.

承担科研项目情况：